Ethylmalonyl Coenzyme A, Free acid

Name: Ethylmalonyl Coenzyme A, Free acid
Brand: Coenza

SKU: A-44-10MG

800,00 €

CAS No.: 6049-57-6
Synonym(s): Ethylmalonyl-CoA
Availability: 6-8 weeks

Quantity

Ethylmalonyl coenzyme A (Ethylmalonyl-CoA) plays an essential role as an intermediate in the ethylmalonyl-CoA pathway, which supports carbon metabolism in bacteria like Methylobacterium extorquens when they grow on ethylamine. It is synthesized from crotonyl-CoA through the action of crotonyl-CoA reductase/carboxylase and is subsequently converted into methylsuccinyl-CoA by ethylmalonyl-CoA mutase (Erb et al., 2007; Pflüger-Grau & Erb, 2014).

1. Erb, T. J., Berg, I. A., Brecht, V., Müller, M., Fuchs, G., & Alber, B. E. (2007). Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: The ethylmalonyl-CoA pathway. Proceedings of the National Academy of Sciences, 104(25), 10631–10636.

2. Pflüger-Grau, K., & Erb, T. J. (2014). A branched pathway for acetyl-CoA assimilation in Methylobacterium extorquensAM1. PNAS, 111(49), 17861–17866.