Benzoyl Coenzyme A, Free acid
CAS No.: 6756-74-7
Synonym(s): Benzoyl Coenzyme A, Benzoyl-CoAAvailability: 2-3 weeks
Benzoyl coenzyme A (benzoyl-CoA) is a central aromatic thioester intermediate in plants and microorganisms. In plants, it is synthesized from phenylalanine via peroxisomal β-oxidation and serves as the starter unit for salicylic acid biosynthesis, a key hormone in plant immunity. This pathway proceeds via benzyl benzoate and benzyl salicylate intermediates.¹ In bacteria, benzoyl-CoA is formed from benzoate by benzoate-CoA ligase (BCL) and acts as a “universal biomarker” for anaerobic degradation of aromatic hydrocarbons.² Under aerobic conditions, it is processed by benzoyl-CoA epoxidase (BoxB) to form (2S,3R)-epoxy-benzoyl-CoA, while under oxygen-limited conditions it undergoes reductive dearomatization.³
Applications
Benzoyl-CoA is involved in salicylic acid biosynthesis in plants and serves as a key intermediate in microbial degradation of aromatic compounds under aerobic and anaerobic conditions.¹ ² ³ Benzoate-CoA ligase and associated pathway genes help characterize these metabolic routes.³ Benzoyl-CoA also supports studies of aerobic Box enzymes and anaerobic benzoyl-CoA reductase, as well as serving as a starter substrate for biphenyl synthase.⁴ ⁵ ⁶ It is relevant to research on histone lysine benzoylation regulated by SIRT2.⁷ Benzoyl-CoA may also serve as an HPLC or LC-MS reference standard.⁸
Other available forms
