Lactyl Coenzyme A, Free acid
CAS No.: 1926-57-4
Synonym(s): Lactyl Coenzyme A, Lactoyl Coenzyme A, Lactyl-CoA, 2-Hydroxyproprionyl-CoA, β-Hydroxypropionyl coenzyme AAvailability: 2-3 weeks
Lactyl coenzyme A, also known as lactoyl-CoA, is a high-energy thioester that links cellular metabolism to both biosynthetic and regulatory processes.¹ ² ³ It functions as the acyl donor for p300-catalyzed histone lysine lactylation (Kla), a chromatin modification that promotes transcription under elevated lactate conditions.² ³ In mammalian nuclei, GTPSCS acts as a lactyl-CoA synthetase supporting this modification, and its activity has been associated with tumorigenesis and radioresistance in glioma cells.² Intracellular lactyl-CoA levels are substantially lower than acetyl-CoA (approximately 20–350-fold), making it a sensitive indicator of glycolytic flux.³
Applications
In metabolic engineering, lactyl-CoA is an important intermediate in the production of biodegradable lactate-based copolymers, including poly(lactate-co-glycolate), and other platform chemicals. CoA-transferases can facilitate its formation for biosynthetic applications.¹ In epigenetic research, lactyl-CoA serves as an acyl donor for studying histone lactylation and lactate-associated gene regulation.² ³ It is also relevant to in vitro lactyltransferase studies, including p300- and KAT2A-mediated histone lactylation, and to studies of ACSS2 as a lactyl-CoA synthetase.⁴ ⁵ Lactyl-CoA is further used in studies of lactate-based polymer biosynthesis, including polylactate and poly(lactate-co-3-hydroxybutyrate) synthesis,⁶ and serves as an HPLC or LC-MS reference standard.⁷
Other available forms
