3-Hydroxypropionyl Coenzyme A, Free acid
CAS No.: 157786-88-4
Synonym(s): 3-Hydroxypropionyl Coenzyme A, 3-Hydroxypropanoyl-CoA, 3-Hydroxypropionyl-CoA, Coenzyme AAvailability: 6-8 weeks
3-hydroxypropionyl coenzyme A (3-hydroxypropionyl-CoA) is a central metabolic intermediate in the 3-hydroxypropionate cycle, an autotrophic CO₂ fixation pathway found in organisms such as Chloroflexus aurantiacus. It is formed from 3-hydroxypropionate by propionyl-CoA synthase and is further metabolized via acrylyl-CoA to propionyl-CoA.¹ In microbial metabolism, it also appears in engineered pathways linked to CoA-dependent processing of hydroxypropionate-derived intermediates.¹ ²
Applications
In biotechnology, 3-hydroxypropionyl-CoA functions as a key intermediate in engineered microbial production of 3-hydroxypropionic acid (3HP) from renewable substrates such as glycerol. In pdu operon-based systems, it participates in metabolic flux toward 3HP and related platform chemicals, including acrylic acid and acrylamide precursors. Because its formation and turnover strongly influence pathway efficiency, it is also used in metabolic flux modeling and pathway optimization to balance enzymatic activity and reduce accumulation of toxic intermediates, thereby improving performance of microbial cell factories for industrial bioproduction.²
Other available forms
