Phenylacetyl Coenzyme A, Free acid

Phenylacetyl coenzyme A (Phenylacetyl-CoA) is used to investigate the mechanisms of the TetR family transcriptional repressor PaaR, which regulates genes involved in phenylacetic acid (PAA) degradation in bacteria like Escherichia coli. Phenylacetyl-CoA binds to PaaR, leading to derepression and activation of the PAA catabolic operon. Phenylacetyl-CoA serves as a substrate for the phenylacetyl-CoA monooxygenase complex, which plays a key role in the breakdown of phenylacetic acid and related aromatic compounds in these bacteria (Grishin et al., 2011; Sakamoto et al., 2011).