Isobutyryl Coenzyme A, Free acid

Isobutyryl coenzyme A (Isobutyryl-CoA) is a short-chain branched acyl-CoA intermediate involved in the biosynthesis of various secondary metabolites, including the antibiotic myxalamid B. It serves as the starter unit for the biosynthetic pathway of these compounds and is essential for studies of enzymes like isobutyryl-CoA mutase (EC 5.4.99.13), which catalyzes the interconversion of acyl-CoA derivatives. Isobutyryl-CoA is also pivotal in research exploring acyl-CoA metabolism, as it participates in reactions linked to fatty acid elongation and branching (Berdy, 2005; Stenson, 2008).