Butyryl Coenzyme A, Sodium salt
CAS No.:125527‑24‑4
Synonym(s): Butyryl Coenzyme A, Butanoyl Coenzyme A, Butyryl-CoAAvailability: 2-3 weeks
Butyryl Coenzyme A (Butyryl-CoA) is a short-chain fatty acyl-CoA and a central intermediate in the microbial synthesis of butyrate, the primary energy source for human colonocytes.¹ ² ³ ⁴ It is formed through multiple bacterial pathways, most notably the acetyl-CoA pathway, which converge at the reduction of crotonyl-CoA to butyryl-CoA via the Bcd–Etf complex, a reaction that conserves energy.¹ ³ In human cells, it also functions as an acyl donor for protein butyrylation, modifying lysine residues on histones H3 and H4 to regulate chromatin structure and gene transcription.²
Applications
Butanoyl Coenzyme A, Sodium Salt, is widely used in biochemical research to study lipid metabolism and enzymatic processes involving acyl-CoA derivatives. It is particularly valuable in studies focused on fatty acid oxidation, biosynthesis, and chain elongation, as well as the regulation of metabolic pathways that generate energy from fatty acids. Researchers also use Butanoyl-CoA Sodium Salt in in vitro assays to investigate the role of butyrate and its derivatives in gut microbiome health, anti-inflammatory responses, and metabolic regulation (Vital et al., 2017; Spry et al., 2008). Its role in lipid metabolism makes it a significant reagent in developing therapeutic strategies for metabolic disorders and diseases linked to fatty acid metabolism (Sibon & Strauss, 2016).
Other available forms
