Hexanoyl Coenzyme A, Sodium salt

Hexanoyl coenzyme A (hexanoyl-CoA) is a medium-chain fatty acyl-CoA that serves as a preferred substrate for ghrelin O-acyltransferase (GOAT) in enzyme assays, outperforming octanoyl-CoA. GOAT, the enzyme responsible for the acylation of ghrelin, exhibits a higher catalytic efficiency with hexanoyl-CoA, which enhances ghrelin’s biological activity in regulating appetite and energy balance. Hexanoyl-CoA acts as a biosynthetic precursor to olivetolic acid, a key intermediate in the production of phytocannabinoids such as cannabigerolic acid (CBGA). This makes hexanoyl-CoA a functionally important molecule in both mammalian metabolism and plant secondary metabolite biosynthesis (Yang et al., 2016; Gagne et al., 2012).