Acetyl Coenzyme A, Trisodium salt
CAS No.: 102029-73-2
Synonym(s): Acetyl Coenzyme A, Acetyl CoA, Acetyl-CoA 3Na
Acetyl Coenzyme A (Acetyl-CoA) is a fundamental metabolic intermediate and a key second messenger coordinating cellular catabolism and anabolism.¹ ² ³ Acetyl-CoA contains a high-energy thioester bond that enables transfer of the acetyl group in a wide range of enzymatic reactions, accounting for its involvement in a large fraction of cellular metabolism.¹ ³ ⁴ Because biological membranes are impermeable to acetyl-CoA, distinct pools exist in mitochondria, cytosol, nucleus, and other organelles, where it is produced via pathways such as pyruvate decarboxylation, β-oxidation, citrate cleavage by ACLY, and acetate utilization by ACSS2.¹ ² ³ ⁴ Its central position in metabolism links energy production, biosynthesis, and regulatory signaling, making it a core integrator of cellular physiological state.¹ ³
Applications
Acetyl Coenzyme A is the entry point of carbon into the TCA cycle and a precursor for ATP production via citrate oxidation.¹ ³ ⁴ Acetyl-CoA is also the main building block for fatty acid, sterol, and isoprenoid biosynthesis, supporting membrane formation and energy storage.¹ ³ ⁴ As a signaling metabolite, Acetyl-CoA is the sole acetyl donor for protein and histone acetylation, regulating gene expression, growth, and metabolism via histone acetyltransferases.¹ ² ³ Its subcellular pools act as nutrient sensors: high levels promote anabolic “fed-state” programs, while depletion induces autophagy and survival responses.¹ ² ⁴ Clinically, dysregulated acetyl-CoA metabolism is linked to cancer (via upregulated ACLY and ACSS2) and aging-related declines in brain acetylation, with therapeutic strategies including acetate donors and calorie restriction mimetics.¹ ³ ⁴
Other available forms
Acetyl Coenzyme A, Sodium salt
Acetyl Coenzyme A, Lithium salt
