Butyryl Coenzyme A, Lithium Salt
CAS No.: 369651-89-8
Synonym(s): Butyryl Coenzyme A, Coenzyme A, S-butanoate, lithium salt
Butyryl Coenzyme A (Butyryl-CoA) is a short-chain fatty acyl-CoA and a central intermediate in the microbial synthesis of butyrate, the primary energy source for human colonocytes.¹ ² ³ ⁴ It is formed through multiple bacterial pathways, most notably the acetyl-CoA pathway, which converge at the reduction of crotonyl-CoA to butyryl-CoA via the Bcd–Etf complex, a reaction that conserves energy.¹ ³ In human cells, Butyryl-CoA also functions as an acyl donor for protein butyrylation, modifying lysine residues on histones H3 and H4 to regulate chromatin structure and gene transcription.²
Applications
Butyryl Coenzyme A is used in microbiology and biochemistry to study butyrate production pathways, including the final conversion to butyrate via butyryl-CoA:acetate CoA-transferase (But) or butyrate kinase (Buk).¹ ³ ⁴ Butyryl-CoA is applied in epigenetics research as a metabolic donor for histone butyrylation, helping to investigate chromatin regulation mechanisms.² In biomedical research, it is used to model the impact of disrupted short-chain fatty acid metabolism in diseases such as inflammatory bowel disease, type II diabetes, and colorectal cancer, as well as to study how gut environmental factors such as pH and nutrient availability influence microbial butyrate production.¹ ² ³ ⁴
Other available forms
