Ethylmalonyl Coenzyme A, Lithium salt
CAS No.: N/A
Synonym(s): Ethylmalonyl Coenzyme A, Ethylmalonyl-CoAAvailability: 6-8 weeks
Ethylmalonyl Coenzyme A is a central intermediate in the ethylmalonyl-CoA pathway, an alternative to the glyoxylate cycle for acetyl-CoA assimilation in α-proteobacteria and actinomycetes. It is formed from crotonyl-CoA by crotonyl-CoA carboxylase/reductase (CCR) via an ATP-independent reductive carboxylation using CO₂ and NADPH. The pathway proceeds through C5 intermediates such as methylsuccinyl-CoA and mesaconyl-CoA, ultimately generating glyoxylate and propionyl-CoA.¹ ² This mechanism is essential for glyoxylate regeneration in methylotrophic metabolism.¹
Applications
Ethylmalonyl-CoA supports growth in bacteria lacking the glyoxylate cycle by enabling acetyl-CoA assimilation and is also a key extender unit in polyketide biosynthesis, contributing butyryl groups to natural products such as monensin A, tylosin, and elaiophylin.² ³ Ethylmalonyl-CoA is used in metabolic engineering to produce modified macrolides (e.g., 6-desmethyl-6-ethylerythromycin A) and value-added chemicals such as 2-ethyl-3-hydroxypropionate and (2S)-ethylmalonate.¹ ³ Its metabolism is also linked to synthesis and utilization of polyhydroxybutyrate (PHB).¹ ²
Other available forms
