Palmitoyl Coenzyme A, Free acid
CAS No.: 1763-10-6
Synonym(s): Palmitoyl Coenzyme A, Coenzyme A, S-hexadecanoate, Palmitoyl-CoAAvailability: 2-3 weeks
Palmitoyl-CoA is a 16-carbon fatty acyl-CoA that serves as the main palmitate donor for protein N-palmitoylation and regulates mitochondrial function.¹ ² In development, it is the substrate for Hedgehog acyltransferase (Hhat), which palmitoylates Sonic hedgehog (Shh) and supports proper signaling through its transport into the ER lumen.² Elevated palmitoyl-CoA is also associated with lipotoxicity, mitochondrial dysfunction, and oxidative stress in metabolic disease.¹
Applications
Palmitoyl-CoA is used to study Hedgehog (Shh) signaling and HHAT function in developmental biology and cancer research, including inhibitor discovery.¹ ² In metabolic research, it serves as a model intermediate for investigating lipotoxicity, mitochondrial dysfunction, reactive oxygen species production, apoptosis, and cardiolipin remodeling in diseases such as NAFLD.¹ It is also a substrate for carnitine palmitoyltransferase 1 (CPT1) and serine palmitoyltransferase (SPT), supporting studies of mitochondrial fatty-acid oxidation and sphingolipid biosynthesis.³ ⁴ As an acyl donor, palmitoyl-CoA is used to investigate HHAT-mediated N-palmitoylation of Sonic Hedgehog and DHHC-mediated protein S-palmitoylation.⁵ ⁶ Palmitoyl-CoA may also be used as an HPLC or LC-MS reference standard.⁷
Other available forms
