Stearoyl Coenzyme A, Free acid
CAS No.: 362-66-3
Synonym(s): Stearoyl Coenzyme A, Stearoyl-CoA, Stearyl-CoA, Octadecanoyl-CoA, Octadecanoyl coenzyme AAvailability: 2-3 weeks
Stearoyl-CoA (C18:0-CoA) is a long-chain saturated fatty acyl-CoA that functions as a key metabolic intermediate in mammalian lipid biosynthesis.¹ ² It is generated from palmitoyl-CoA via fatty acyl-CoA elongase (Elovl6), under transcriptional control of SREBP-1, and serves as a central substrate in lipid metabolic pathways.¹
Applications
Stearoyl-CoA is a key substrate for stearoyl-CoA desaturase (SCD), which converts it to oleoyl-CoA, a precursor for triglycerides, cholesteryl esters, phospholipids, and other lipids. It is used to study lipid metabolism and SCD activity, with the oleate-to-stearate ratio serving as an indicator of desaturation and lipid metabolic status.² Stearoyl-CoA is also used in SCD enzyme kinetics and inhibitor-screening assays.³ ⁴ Additionally, Stearoyl-CoA is relevant to studies of fatty-acid elongation by ELOVL enzymes and long-chain acyl-CoA elongase activity.⁵ ⁶ Stearoyl-CoA might be used as an HPLC or LC-MS reference standard.⁷
Other available forms
