Lauroyl Coenzyme A, Lithium salt
CAS No.: 190063-12-8
Synonym(s): Lauroyl Coenzyme A, Dodecanoyl-Coenzyme A lithium salt, C12-CoA
Lauroyl-CoA is a 12-carbon acyl-CoA that functions as a primer in mycolic acid biosynthesis in Mycobacterium tuberculosis, where it is utilized by β-ketoacyl-ACP synthase III (FabH). Structural studies show that it binds within an elongated hydrophobic channel, enabling transfer of the acyl group to the enzyme’s active-site cysteine. Lauroyl Coenzyme A also acts as a substrate for FabH in type II fatty acid synthesis (FASII) systems in bacteria and plants.¹
Applications
Lauroyl-CoA is used as a high-performance substrate in peroxisomal fatty acyl-CoA oxidase assays, providing ~4.5-fold higher activity than palmitoyl-CoA while avoiding substrate inhibition. It enables linear assay conditions without the need for albumin and supports sensitive fluorometric detection of hydrogen peroxide. These properties make Lauroyl-CoA useful for studying peroxisomal β-oxidation and enzyme regulation.² Additionally, FabH–lauroyl-CoA structural data are applied in drug discovery to guide development of selective antimicrobial inhibitors.¹
Other available forms
