5',3'-TIPS 5-methyluridine
CAS No.: 130983-87-8
Synonym(s): 5'3'-TIPS 5-methyluridine, 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-5-methyluridine
Availability: 4-6 weeks
5′,3′-TIPS 5-methyluridine is a silyl-protected nucleoside derivative in which the 3′- and 5′-hydroxyl groups are simultaneously protected by a cyclic tetraisopropyldisiloxane (TIPS) bridge. This modification introduces significant steric bulk and lipophilicity, making it useful for studying the impact of hydrophobic protecting groups on nucleoside structure and function.¹
Applications
5′,3′-TIPS 5-methyluridine is primarily used in medicinal chemistry research, where it has been investigated for antiproliferative effects in human cancer cell lines, including glioma models. More broadly, such derivatives are used to explore how hydrophobic modifications influence cellular uptake, metabolic stability, and the overall therapeutic performance of nucleoside-based compounds.¹
