5'-Deoxy-5'-iodothymidine

5′-Deoxy-5′-iodothymidine is a modified nucleoside in which the 5′-hydroxyl group of thymidine is replaced by iodine, creating a highly reactive intermediate for nucleophilic substitution. This reactivity makes it a versatile precursor for the synthesis of diverse thymidine analogues.¹ ²

 

Applications

 

5′-Deoxy-5′-iodothymidine is widely used as a synthetic intermediate in nucleoside chemistry. It serves as a precursor for phosphonic acid derivatives and for the synthesis of 5′-azido-5′-deoxythymidine used in “click DNA” technologies.¹ ² It is also applied in medicinal chemistry to generate sulfamide analogues targeting enzymes such as thymidine monophosphate kinase in Mycobacterium tuberculosis.²