Succinyl Coenzyme A, Lithium salt
CAS No.: N/A
Synonym(s): Succinyl Coenzyme A, Succinyl-CoA lithium salt, Succinyl-CoA Li saltAvailability: 6-8 weeks
Succinyl-CoA is a central intermediate of the tricarboxylic acid (TCA) cycle that links primary metabolism with biosynthetic pathways, including polyketide antibiotic production and related metabolic engineering systems.¹ ² In organisms such as Saccharopolyspora erythraea, it provides key building blocks for erythromycin biosynthesis, and its levels are regulated in part by lysine succinylation, which can inhibit enzymes such as aconitase when excessive.¹ Clinically, reduced myocardial succinyl-CoA levels are associated with chronic heart failure, where depletion impairs mitochondrial oxidative phosphorylation due to increased utilization in heme synthesis and ketolysis.³
Applications
Succinyl-CoA is targeted in metabolic engineering to improve antibiotic production, where CRISPRi-based regulation enhances erythromycin titers by limiting hypersuccinylation effects.¹ It is also used in green chemistry platforms, including one-pot enzymatic cascades that synthesize succinyl-CoA and 5-aminolevulinic acid (5-ALA) from low-cost substrates with integrated CO₂ capture.² In clinical research, restoration of succinyl-CoA levels improves mitochondrial function and slows progression of heart failure in experimental models.³
Other available forms
