Coenzyme A, Sodium salt
CAS No.: 55672-92-9
Synonym(s): CoA Na2
Coenzyme A (CoA) is an indispensable and ubiquitous metabolic cofactor for all organisms. It is synthesized in an evolutionarily conserved pathway by enzymatic conjugation of cysteine, pantothenate (Vitamin B5), and ATP. This unique chemical structure allows CoA to employ its highly reactive thiol group for diverse biochemical reactions. CoA is involved in approximately 9% of all metabolic pathways, including the tricarboxylic acid (TCA) cycle, fatty acid regulation, amino acid synthesis, and lipid metabolism (Leonardi et al., 2005; Daugherty et al., 2002).
ApplicationsCoenzyme A Sodium Salt is widely used in metabolic research and biochemical studies due to its critical role in various enzymatic reactions and metabolic pathways. It is particularly valuable for investigating the mechanisms of energy production, lipid metabolism, and biosynthesis of key cellular components. Researchers utilize CoA Sodium Salt in studies related to cellular signaling, redox regulation, and metabolic diseases to understand better CoA's regulatory functions and its potential as a therapeutic target (Leonardi et al., 2005; Sibon & Strauss, 2016). Furthermore, its role in fatty acid oxidation and synthesis makes it a crucial reagent in developing treatments for metabolic disorders and understanding microbial metabolism (Spry et al., 2008).