Acetyl Coenzyme A, Sodium salt
CAS No.: 102029-73-2
Synonym(s): Acetyl-CoA Na
Acetyl Coenzyme A (Acetyl-CoA) is a vital molecule in cellular metabolism, serving as a central intermediate in various biochemical processes. It is synthesized by the acetylation of Coenzyme A (CoA) through enzymatic reactions involving pyruvate dehydrogenase, β-oxidation of fatty acids, and amino acid catabolism. The unique structure of Acetyl-CoA, with its reactive acetyl group, allows it to participate in numerous biochemical reactions, including the tricarboxylic acid (TCA) cycle, fatty acid synthesis, and cholesterol metabolism, making it an essential cofactor in cellular energy production and biosynthetic pathways (Pietrocola et al., 2015; Shi & Tu, 2015).
ApplicationsAcetyl Coenzyme A, Sodium Salt, is widely used in research to study cellular metabolism and enzyme functions, particularly those involving acetylation reactions. It is an important reagent for investigating metabolic pathways such as the TCA cycle, where Acetyl-CoA is a key substrate for citrate synthesis, and for studying fatty acid and cholesterol biosynthesis. Researchers utilize Acetyl-CoA Sodium Salt in in vitro assays to understand enzyme mechanisms, epigenetic modifications, and metabolic regulation in health and disease contexts (Pietrocola et al., 2015; Sibon & Strauss, 2016). Additionally, it plays a significant role in developing therapeutic strategies targeting metabolic diseases, cancer metabolism, and microbial infections (Spry et al., 2008).