Acetyl Coenzyme A, Lithium salt
CAS No.: 32140-51-5
Synonym(s): Acetyl-CoA Li
Acetyl Coenzyme A (Acetyl-CoA) is a central molecule in cellular metabolism, playing a pivotal role in energy production and biosynthesis. It is generated by the acetylation of Coenzyme A (CoA) through key enzymatic processes, including pyruvate decarboxylation by pyruvate dehydrogenase, fatty acid β-oxidation, and the catabolism of certain amino acids. Acetyl-CoA's reactive acetyl group enables its participation in various biochemical pathways, such as the tricarboxylic acid (TCA) cycle, fatty acid synthesis, and cholesterol metabolism, making it essential for cellular energy and biosynthetic processes (Pietrocola et al., 2015; Shi & Tu, 2015).
ApplicationsAcetyl Coenzyme A, Lithium Salt, is a key reagent used in metabolic research to study enzymatic functions and metabolic pathways involving acetylation. It is utilized in in vitro studies to explore the TCA cycle, where Acetyl-CoA serves as a critical substrate for citrate formation, and in the biosynthesis of fatty acids and cholesterol. It is also essential for examining acetyl-CoA's role in epigenetic regulation, such as histone acetylation, which affects gene expression and cellular differentiation (Pietrocola et al., 2015; Sibon & Strauss, 2016). Additionally, Acetyl-CoA Lithium Salt is used in research on metabolic diseases, cancer metabolism, and antimicrobial strategies, given its central role in cell metabolism and growth (Spry et al., 2008).