2-Hydroxybenzoyl Coenzyme A, Lithium salt

2-Hydroxybenzoyl-CoA (salicyl-CoA) is an aromatic thioester intermediate formed by activation of salicylic acid (2-hydroxybenzoate) with coenzyme A.¹ ² It participates in anaerobic microbial metabolism, where it is converted to benzoyl-CoA for further degradation of aromatic compounds.¹ In mammals, it is involved in salicylate metabolism, including pathways derived from aspirin. In solution, salicyl-CoA adopts a folded conformation stabilized by intramolecular π–π interactions, which may influence enzyme recognition and reactivity.²

Applications

2-Hydroxybenzoyl-CoA is used to study aromatic compound degradation and enzyme mechanisms.¹ ² In microbiology, it serves as a model intermediate for anaerobic pathways converting salicylate to benzoyl-CoA.¹ Its defined folded structure also makes it useful for investigating substrate recognition, conformational dynamics, and catalytic specificity of CoA-dependent enzymes.²