Propanoyl Coenzyme A, Sodium salt

Propanoyl Coenzyme A (Propanoyl-CoA), also known as propionyl-CoA, is a three-carbon thioester derivative of Coenzyme A that plays a crucial role in intermediary metabolism. It is formed during the catabolism of odd-chain fatty acids, certain amino acids (such as valine, isoleucine, and methionine), and cholesterol. Propanoyl-CoA serves as an intermediate in the conversion of propionate to succinyl-CoA, a key metabolite in the tricarboxylic acid (TCA) cycle. This pathway is vital for energy production and the gluconeogenic process, linking lipid and carbohydrate metabolism in cells (Horswill & Escalante-Semerena, 1999; Luo et al., 2016).

Applications

Propanoyl Coenzyme A, Sodium Salt, is commonly used in biochemical and metabolic research to study enzyme activities and metabolic pathways involving short-chain fatty acids. It is particularly valuable for investigating the metabolism of odd-chain fatty acids, amino acid degradation, and their integration into the TCA cycle. Researchers use Propanoyl-CoA Sodium Salt in vitro to analyze metabolic flux, study enzyme kinetics, and understand the regulatory mechanisms of CoA derivatives under normal and pathological conditions (Horswill & Escalante-Semerena, 1999; Spry et al., 2008). Additionally, its relevance in metabolic regulation makes it a useful reagent for developing therapeutic approaches to treat metabolic disorders and studying microbial metabolic processes (Sibon & Strauss, 2016).