Pentanoyl Coenzyme A, Free acid

Pentanoyl Coenzyme A (Pentanoyl-CoA), also known as valeroyl-CoA, is a thioester derivative of Coenzyme A involved in fatty acid metabolism. As a medium-chain acyl-CoA, it serves as an intermediate in various metabolic pathways, including the oxidation and elongation of fatty acids and the biosynthesis of complex lipids. Pentanoyl-CoA is also a substrate for several enzymes involved in energy production and cellular signaling. Its reactive acyl group allows it to participate in diverse biochemical reactions, playing a critical role in cellular energy homeostasis and metabolic regulation (Ellis et al., 2021; Liu et al., 2013).

Applications

Pentanoyl Coenzyme A, Free Acid, is widely utilized in metabolic research to study fatty acid oxidation and chain elongation processes. It is particularly valuable for examining the role of medium-chain fatty acid metabolism in energy production and cellular function. Researchers use Pentanoyl-CoA Free Acid in in vitro assays to investigate enzyme kinetics, metabolic flux, and regulatory mechanisms of CoA derivatives in both normal and pathological states (Ellis et al., 2021; Spry et al., 2008). Its involvement in lipid metabolism makes it an important reagent for developing therapeutic strategies for metabolic diseases and studying microbial metabolism (Sibon & Strauss, 2016).