Butanoyl Coenzyme A, Sodium salt

Butanoyl Coenzyme A (Butanoyl-CoA), also known as butyryl-CoA, is a thioester of Coenzyme A that plays a crucial role in fatty acid metabolism and energy production. It is formed as an intermediate during the β-oxidation of fatty acids and serves as a substrate for various enzymes involved in lipid metabolism and biosynthetic pathways. Butanoyl-CoA is important in the synthesis of butyrate, a short-chain fatty acid that is a key energy source for colonocytes and has significant roles in maintaining gut health and modulating inflammatory responses. It also functions as an acyl donor in the elongation and degradation of fatty acids, making it a critical intermediate in cellular metabolism (Vital et al., 2017; Louis & Flint, 2017).

Applications

Butanoyl Coenzyme A, Sodium Salt, is widely used in biochemical research to study lipid metabolism and enzymatic processes involving acyl-CoA derivatives. It is particularly valuable in studies focused on fatty acid oxidation, biosynthesis, and chain elongation, as well as the regulation of metabolic pathways that generate energy from fatty acids. Researchers also use Butanoyl-CoA Sodium Salt in in vitro assays to investigate the role of butyrate and its derivatives in gut microbiome health, anti-inflammatory responses, and metabolic regulation (Vital et al., 2017; Spry et al., 2008). Its role in lipid metabolism makes it a significant reagent in developing therapeutic strategies for metabolic disorders and diseases linked to fatty acid metabolism (Sibon & Strauss, 2016).